Ridding the home of bed bugs is somewhat similar to the process for ridding the home of lice. All bedding should be removed and washed in hot water. Vacuuming floors, carpeting, and window treatments will also help minimize the degree of infestation. The mattress, box springs and the bed frame should be sprayed with rubbing alcohol in order to kill bedbugs. Be sure to wipe down the frame using hot water followed by a dry cloth in order to prevent the rubbing alcohol from damaging the wood or metal of the bed frame.